GGH - gamma-glutamyl hydrolase Gene

Also Known as GH; GATD10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8836

About GGH

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,015,079-63,038,806 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Broad expression in kidney (RPKM 36.6), liver (RPKM 31.0) and 19 other tissues.

Summary

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

GGH Products (2)

mRNA Protein Name
NM_001410926.1 NP_001397855.1 gamma-glutamyl hydrolase isoform 2 precursor
NM_003878.3 NP_003869.1 gamma-glutamyl hydrolase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gamma-glutamyl-peptidase activity IDA
IDA: Inferred from direct assay
11005824 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
25645918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGH Protein Structure

Peptidase_C26

Peptidase_C26: Peptidase C26 (34 - 246)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
Protein Preferred Names Protein Names

gamma-glutamyl hydrolase

  • gamma-Glu-X carboxypeptidase

GGH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GGH Q92820 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
GGH Q92820 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
GGH Q92820 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GGH Proteins

Cat. No. Product Name Accession Purity
HY-P76953 GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His) Q92820/NP_003869.1(R25-D318) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Tropical Sprue

  • Tropical Steatorrhea

  • Tropical Enteropathy

  • Sprue, Tropical

  • Sprue - Tropical

  • Idiopathic Tropical Malabsorption Syndrome

  • Tropical Steatorrhoea

  • Tropical Diarrhoea

  • Ts - [Tropical Sprue]

  • Psilosis

  • Sprue Nos
Pulmonary Neuroendocrine Tumor

  • Neuroendocrine Neoplasm Of Lung
Folate Malabsorption, Hereditary

  • Hereditary Folate Malabsorption

  • Congenital Defect Of Folate Absorption

  • Congenital Folate Malabsorption

  • Folic Acid Transport Defect

  • HFM
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05399 GGH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18735 Ggh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25222 Ggh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GGH VGNC VGNC:41198
Mus musculus GGH MGD MGI:1329035
Felis catus GGH VGNC VGNC:62537
Macaca mulatta GGH VGNC VGNC:104457
Bos taurus GGH VGNC VGNC:29340
Rattus norvegicus GGH RGD RGD:2682
Others GGH NCBI