GGH - gamma-glutamyl hydrolase Gene

Homo sapiens

Also known as GH; GATD10

Gene ID: 8836 | Gene type: protein coding

About GGH

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,015,079-63,038,806 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Broad expression in kidney (RPKM 36.6), liver (RPKM 31.0) and 19 other tissues.

Summary

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

GGH Products(2)

mRNA	Protein	Name
NM_001410926.1	NP_001397855.1	gamma-glutamyl hydrolase isoform 2 precursor
NM_003878.3	NP_003869.1	gamma-glutamyl hydrolase isoform 1 precursor

GGH Protein Structure

Peptidase_C26

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

gamma-glutamyl hydrolase

gamma-Glu-X carboxypeptidase

Recombinant GGH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76953	GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His)	Q92820/NP_003869.1(M25-D318)	≥95%

Related Diseases

Diseases

Alias

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05399	GGH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GGH	VGNC	VGNC:41198
Mus musculus	GGH	MGD	MGI:1329035
Felis catus	GGH	VGNC	VGNC:62537
Macaca mulatta	GGH	VGNC	VGNC:104457
Bos taurus	GGH	VGNC	VGNC:29340
Rattus norvegicus	GGH	RGD	RGD:2682
Others	GGH	NCBI