STARD13 - StAR related lipid transfer domain containing 13 Gene

Also Known as DLC2; GT650; ARHGAP37; LINC00464

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90627

About STARD13

Cytogenetic location: 13q13.1-q13.2 Genomic coordinates (GRCh38): 13:33,103,137-33,676,794 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 9.3), thyroid (RPKM 7.8) and 24 other tissues.

Summary

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

STARD13 Products (7)

mRNA Protein Name
NM_001243466.2 NP_001230395.1 stAR-related lipid transfer protein 13 isoform 5
NM_001243474.2 NP_001230403.1 stAR-related lipid transfer protein 13 isoform 6
NM_001243476.3 NP_001230405.1 stAR-related lipid transfer protein 13 isoform 4
NM_001411014.1 NP_001397943.1 stAR-related lipid transfer protein 13 isoform 7
NM_052851.3 NP_443083.1 stAR-related lipid transfer protein 13 isoform 3
NM_178006.4 NP_821074.1 stAR-related lipid transfer protein 13 isoform 1
NM_178007.3 NP_821075.1 stAR-related lipid transfer protein 13 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14697242 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within endothelial cell migration IGI
IGI: Inferred from genetic interaction
20208559 GOA
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
20208559 GOA
acts upstream of or within endothelial tube lumen extension IGI
IGI: Inferred from genetic interaction
20208559 GOA
acts upstream of or within endothelial tube lumen extension IMP
IMP: Inferred from mutant phenotype
20208559 GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis IGI
IGI: Inferred from genetic interaction
20208559 GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
20208559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STARD13 Protein Structure

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (61 - 120)

RhoGAP

RhoGAP: RhoGAP domain (677 - 820)

START

START: START domain (912 - 1098)

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  • 800
  • 1000
  • 1113 a.a.
Protein Preferred Names Protein Names

stAR-related lipid transfer protein 13

  • Rho GTPase activating protein on chromosome 13q12

STARD13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STARD13 Q9Y3M8 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
14697242
Intra
STARD13 Q9Y3M8 TAX1BP1 Homo sapiens Q86VP1
Y2H
14697242
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13877 STARD13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STARD13 VGNC VGNC:65752
Mus musculus STARD13 MGD MGI:2385331
Macaca mulatta STARD13 VGNC VGNC:77962
Canis familiaris STARD13 VGNC VGNC:46881
Bos taurus STARD13 VGNC VGNC:35362
Rattus norvegicus STARD13 RGD RGD:1564816