RRP9 - ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Gene

Also Known as U3-55K; RNU3IP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9136

About RRP9

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,933,429-51,941,904 (from NCBI)

This gene has 1 transcript (splice variant) and 205 orthologues. Ubiquitous expression in appendix (RPKM 6.7), adrenal (RPKM 6.6) and 25 other tissues.

Summary

This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]

RRP9 Products (1)

mRNA Protein Name
NM_004704.5 NP_004695.1 U3 small nucleolar RNA-interacting protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to U3 snoRNA binding IDA
IDA: Inferred from direct assay
9418896 GOA
enables U3 snoRNA binding IDA
IDA: Inferred from direct assay
26867678 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26867678 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA processing IDA
IDA: Inferred from direct assay
26867678 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of box C/D methylation guide snoRNP complex IDA
IDA: Inferred from direct assay
9418896 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
9418896 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRP9 Protein Structure

WD40

WD40: WD domain, G-beta repeat (139 - 174)

WD40

WD40: WD domain, G-beta repeat (196 - 227)

WD40

WD40: WD domain, G-beta repeat (232 - 269)

WD40

WD40: WD domain, G-beta repeat (276 - 311)

WD40

WD40: WD domain, G-beta repeat (317 - 350)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

U3 small nucleolar RNA-interacting protein 2

  • RNA, U3 small nucleolar interacting protein 2

RRP9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRP9 O43818 NOP56 Homo sapiens O00567
Anti Tag CoIP
33961781
Intra
RRP9 O43818 NOP56 Homo sapiens O00567
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12293 RRP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RRP9 VGNC VGNC:77028
Felis catus RRP9 VGNC VGNC:64783
Bos taurus RRP9 VGNC VGNC:34172
Canis familiaris RRP9 VGNC VGNC:45767
Mus musculus RRP9 MGD MGI:2384313
Rattus norvegicus RRP9 RGD RGD:1307881
Others RRP9 NCBI