TRMT10A - tRNA methyltransferase 10A Gene

Also Known as MSSGM; TRM10; MSSGM1; RG9MTD2; HEL-S-88

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93587

About TRMT10A

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,546,711-99,564,039 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 4.1), thyroid (RPKM 2.7) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

TRMT10A Products (6)

mRNA Protein Name
NM_001134665.3 NP_001128137.1 tRNA methyltransferase 10 homolog A isoform 1
NM_001134666.3 NP_001128138.1 tRNA methyltransferase 10 homolog A isoform 1
NM_001375880.1 NP_001362809.1 tRNA methyltransferase 10 homolog A isoform 1
NM_001375881.1 NP_001362810.1 tRNA methyltransferase 10 homolog A isoform 1
NM_001375882.1 NP_001362811.1 tRNA methyltransferase 10 homolog A isoform 2
NM_152292.5 NP_689505.1 tRNA methyltransferase 10 homolog A isoform 1

TRMT10A Protein Structure

tRNA_m1G_MT

tRNA_m1G_MT: tRNA (Guanine-1)-methyltransferase (110 - 276)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

tRNA methyltransferase 10 homolog A

  • RNA (guanine-9-)-methyltransferase domain-containing protein 2

TRMT10A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRMT10A Q8TBZ6 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
TRMT10A Q8TBZ6 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
TRMT10A Q8TBZ6 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephaly, Short Stature, And Impaired Glucose Metabolism 1

  • MSSGM1

  • Mssgm

  • Microcephaly, Short Stature, And Impaired Glucose Metabolism
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Hyperinsulinemic Hypoglycemia

  • Nesidioblastosis

  • Islet Cell Hyperplasia

  • Persistent Hyperinsulinemia Hypoglycemia Of Infancy

  • Hyperinsulinemic Hypoglycaemia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Lipodystrophy, Congenital Generalized, Type 1

  • Congenital Generalized Lipodystrophy Type 1

  • Bscl1

  • CGL1

  • Berardinelli-Seip Congenital Lipodystrophy, Type 1

  • Brunzell Syndrome Agpat2-Related

  • Berardinelli-Seip Congenital Lipodystrophy Type 1

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 1

  • Brunzell Syndrome, Agpat2-Related

  • Agpat2-Related Brunzell Syndrome

  • Congenital Generalized Lipodystrophy 1

  • Berardinelli-Seip Syndrome

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Lipodystrophy, Generalized, Congenital, Type 1

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Usher Syndrome, Type Iic

  • Usher Syndrome Type 2c

  • USH2C

  • Usher Syndrome, Type 2c

  • Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

  • Usher Syndrome Type Iic

  • Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

  • Usher Syndrome 2c

  • Usher'S Syndrome Type 2c

  • Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15087 TRMT10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRMT10A VGNC VGNC:66566
Macaca mulatta TRMT10A VGNC VGNC:107207
Bos taurus TRMT10A VGNC VGNC:36366
Mus musculus TRMT10A MGD MGI:1920421
Rattus norvegicus TRMT10A RGD RGD:1594565
Canis familiaris TRMT10A VGNC VGNC:47851
Others TRMT10A NCBI