Dtnbp1 - dystrobrevin binding protein 1 Gene

Also Known as sdy; Bloc1s8; dysbindin; 5430437B18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94245

Summary

Involved in several processes, including anterograde synaptic vesicle transport; plasma membrane bounded cell projection organization; and regulation of secretion by cell. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of protein serine/threonine kinase activity; and platelet dense granule organization. Located in several cellular components, including growth cone; hippocampal mossy fiber to CA3 synapse; and sarcolemma. Part of BLOC-1 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic vesicle membrane. Is expressed in central nervous system and retina. Used to study Hermansky-Pudlak syndrome 7; platelet storage pool deficiency; and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dtnbp1 Products (1)

mRNA Protein Name
NM_025772.4 NP_080048.2 dysbindin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11316798 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
16980328 MGI
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
21998198 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
1936982 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
28576874 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
25297099 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
28576874 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
26294018 MGI
acts upstream of or within negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
25297099 MGI
acts upstream of or within negative regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
25297099 MGI
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
16980328 MGI
involved in organelle organization IDA
IDA: Inferred from direct assay
12923531 MGI
acts upstream of or within platelet dense granule organization IMP
IMP: Inferred from mutant phenotype
1936982 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
20921223 MGI
involved in positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
18504299 MGI
acts upstream of or within protein transmembrane transport IMP
IMP: Inferred from mutant phenotype
28576874 MGI
involved in regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
19094965 MGI
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
19887632 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
18504299 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
18504299 MGI
Cellular Component GO Annotation Evidence References Source
part of BLOC-1 complex IDA
IDA: Inferred from direct assay
17182842 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16980328 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
18504299 MGI
is active in asymmetric synapse IDA
IDA: Inferred from direct assay
16980328 MGI
located in axon IDA
IDA: Inferred from direct assay
11316798 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11316798 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
16980328 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
16980328 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18504299 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18504299 MGI
located in growth cone IDA
IDA: Inferred from direct assay
16980328 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
16980328 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11316798 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11316798 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
16980328 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
16980328 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
11316798 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
14688250 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
16980328 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
16980328 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dysbindin

  • BLOC-1 subunit 8

  • HPS7 protein homolog

  • biogenesis of lysosome-related organelles complex 1 subunit 8

  • dysbindin-1

  • hermansky-Pudlak syndrome 7 protein homolog

  • sandy

Dtnbp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dtnbp1 Q91WZ8 Dtna Mus musculus Q9D2N4
Anti Bait CoIP
11316798
Intra
Dtnbp1 Q91WZ8 Dtna Mus musculus Q9D2N4
Y2H
11316798
Intra
Dtnbp1 Q91WZ8 Dtna Mus musculus Q9D2N4
IF
11316798
Intra
Dtnbp1 Q91WZ8 Cmya5 Mus musculus Q70KF4
Pull Down
14688250
Intra
Dtnbp1 Q91WZ8 Cmya5 Mus musculus Q70KF4
Y2H
14688250
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04037 DTNBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dtnbp1 NCBI NCBI:84062