ATP5PF - Atp5pf ATP synthase peripheral stalk subunit F6 Gene

Rattus norvegicus

Also known as Atp5j

Gene ID: 94271 | Gene type: protein coding

About ATP5PF

Summary

Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface; extracellular space; and mitochondrion. Part of mitochondrial proton-transporting ATP Synthase complex, coupling factor F(o). Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP Synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Apr 2022]

ATP5PF Products(1)

mRNA	Protein	Name
NM_053602.2	NP_446054.1	ATP synthase-coupling factor 6, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to ATP hydrolysis activity	IDA IDA: Inferred from direct assay	1829963	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	1429613	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	9822642	RGD
involved in negative regulation of prostaglandin secretion	IDA IDA: Inferred from direct assay	11581303	RGD
involved in negative regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	19474762	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	11581303	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	11581303	RGD
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	12686462	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	24719897	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11581303	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	27916219	RGD
part of proton-transporting ATP synthase complex	IDA IDA: Inferred from direct assay	17575325	RGD
part of proton-transporting ATP synthase complex, coupling factor F(o)	IDA IDA: Inferred from direct assay	10887193	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP synthase-coupling factor 6, mitochondrial

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATPase subunit F6	coupling factor 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01212	ATP5PF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ATP5PF	NCBI	NCBI:522

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