Prg4 - proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Gene

Also Known as MSF; SZP; CACP; JCAP; DOL54; lubricin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 96875

Summary

Predicted to enable polysaccharide binding activity and scavenger receptor activity. Acts upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Located in extracellular space. Is expressed in brain; larynx; musculoskeletal system; and spinal component of peripheral nervous system. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]

Prg4 Products (2)

mRNA Protein Name
NM_001110146.1 NP_001103616.1 proteoglycan 4 isoform 2 precursor
NM_021400.3 NP_067375.3 proteoglycan 4 isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15719068 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15719068 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteoglycan 4

  • megakaryocyte-stimulating factor

  • proteoglycan 3

  • superficial zone proteoglycan

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11090 PRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19634 Prg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26129 Prg4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prg4 NCBI NCBI:10216