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ACYP2 - acylphosphatase 2 Gene

Also Known as ACYM; ACYP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 98

About ACYP2

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,971,113-54,305,300 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 3.1), heart (RPKM 2.8) and 25 other tissues.

Summary

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ACYP2 Products (6)

mRNA	Protein	Name
NM_001320586.2	NP_001307515.1	acylphosphatase-2 isoform 1
NM_001320587.2	NP_001307516.1	acylphosphatase-2 isoform 2
NM_001320588.2	NP_001307517.1	acylphosphatase-2 isoform 4
NM_001320589.2	NP_001307518.1	acylphosphatase-2 isoform 5
NM_001320590.2	NP_001307519.1	acylphosphatase-2 isoform 6
NM_138448.4	NP_612457.1	acylphosphatase-2 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12374855	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACYP2 Protein Structure

Acylphosphatase

0
99 a.a.

Protein Preferred Names	Protein Names
acylphosphatase-2	acylphosphatase 2, muscle type

ACYP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ACYP2	P14621	GFPT2	Homo sapiens	O94808	Anti Tag CoIP	33961781
Intra	ACYP2	P14621	ACYP2	Homo sapiens	P14621	Fluorescence Spectr	12374855
Intra	ACYP2	P14621	SULT2B1	Homo sapiens	O00204	Validated Y2H	25416956
Intra	ACYP2	P14621	ACYP2	Homo sapiens	P14621	Fluorescence Spectr	16084386
Intra	ACYP2	P14621	ACYP2	Homo sapiens	P14621	DLS	16084386
Intra	ACYP2	P14621	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	33961781
Intra	ACYP2	P14621	OGA	Homo sapiens	O60502	Anti Tag CoIP	33961781
Intra	ACYP2	P14621	BCS1L	Homo sapiens	Q9Y276	Anti Tag CoIP	33961781
Intra	ACYP2	P14621	SULT2B1	Homo sapiens	O00204	Y2H Prey Pooling	25416956
Intra	ACYP2	P14621	CREBZF	Homo sapiens	Q9NS37	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACYP2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7459	Acylphosphatase-2/ACYP2 Protein, Human (GST)	P14621 (S2-Y99)	≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00257	ACYP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20362	Acyp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26871	Acyp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ACYP2	VGNC	VGNC:98504
Mus musculus	ACYP2	MGD	MGI:1922822
Rattus norvegicus	ACYP2	RGD	RGD:1595836
Canis familiaris	ACYP2	VGNC	VGNC:37567
Macaca mulatta	ACYP2	VGNC	VGNC:82096
Bos taurus	ACYP2	VGNC	VGNC:25599
Others	ACYP2	NCBI