Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC50s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues.
For research use only. We do not sell to patients.
- CAS No.: 2775428-94-7
- Formula: C31H18D15BrN4O9
- Molecular Weight:700.61
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
<5 nM
Compound: 3f
|
Antitumor activity against human A549 cells incubated for 48 hrs
Antitumor activity against human A549 cells incubated for 48 hrs
|
[PMID: 39026395] |
| BMDM | IC50 |
1.42 μM
Compound: 3f
|
Growth inhibition of mouse BMDMs
Growth inhibition of mouse BMDMs
|
[PMID: 39026395] |
| HCT-116 | GI50 |
<5 nM
Compound: 3f
|
Antitumor activity against human HCT-116 cells incubated for 48 hrs
Antitumor activity against human HCT-116 cells incubated for 48 hrs
|
[PMID: 39026395] |
| Hs-578T | GI50 |
<5 nM
Compound: 3f
|
Antitumor activity against human Hs-578T cells incubated for 48 hrs
Antitumor activity against human Hs-578T cells incubated for 48 hrs
|
[PMID: 39026395] |
| MDA-MB-231 | GI50 |
<1 nM
Compound: 3f
|
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 2D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 2D microtiter assay
|
[PMID: 39026395] |
| MDA-MB-231 | GI50 |
<1 nM
Compound: 3f
|
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 2D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 2D microtiter assay
|
[PMID: 39026395] |
| MDA-MB-231 | GI50 |
2.12 nM
Compound: 3f
|
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 3D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 3D microtiter assay
|
[PMID: 39026395] |
| MDA-MB-231 | GI50 |
9.47 nM
Compound: 3f
|
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 3D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 3D microtiter assay
|
[PMID: 39026395] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 2775428-94-7
-
Unlabeled Cas 1961257-47-5
-
Molecular Weight 700.61
-
Formula C31H18D15BrN4O9
-
SMILES
O=C(N[C@H]1CC(N(OC([2H])([2H])[2H])C([2H])([2H])[2H])=O)C2=CC(OC3=CC(C)=CC(C)=C3)=C(C=C2NC1=O)NC(C4=C(C(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C4)OC([2H])([2H])[2H])Br)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-183 Related Classifications
HY-159176 Related Classifications
Powered by Bioz