Pbx3 - pre B cell leukemia homeobox 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18516

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult locomotory behavior; nervous system development; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human PBX3 (PBX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pbx3 Products (2)

mRNA Protein Name
NM_001290576.1 NP_001277505.1 pre-B-cell leukemia transcription factor 3 isoform PBX3b
NM_016768.2 NP_058048.1 pre-B-cell leukemia transcription factor 3 isoform PBX3a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15466398 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15466398 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10381567 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16847320 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
18155191 MGI
acts upstream of or within dorsal spinal cord development IMP
IMP: Inferred from mutant phenotype
18155191 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
18155191 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15466398 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
15527896 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
15466398 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10842069 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10381567 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pre-B-cell leukemia transcription factor 3

  • homeobox protein PBX3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3245A HXR9 hydrochloride 99.48% Unkown
HY-P3245 HXR9 Inducer / Unkown
HY-RS10108 PBX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22270 Pbx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28793 Pbx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pbx3 NCBI NCBI:5090