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Bemcentinib

(別名: R428; BGB324)
63 Cited Publications
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Based on 63 publication(s) in Google Scholar

Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer.

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  • 純度: 99.92%
  • CAS 番号: 1037624-75-1
  • 分子式: C30H34N8
  • 分子量:506.64
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Bemcentinib Chemical Structure
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Bemcentinib Chemical Structure
    Bemcentinib 構造式
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
  • Experimental Validation Results for Bemcentinib
CAS 番号: 1037624-75-1
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  • Bemcentinib Chemical Structure
    Bemcentinib Chemical Structure
    1/16
  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Feb 22;10(1):7. [Abstract]

    Customer Validation
     Bemcentinib (BGB324; 1 μM; 30 min) partially blocks the activation of HSC by rGAS6 in LX-2 cells.

  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2018 Dec 10;34(6):954-969.e4. [Abstract]

    Customer Validation
     Western blot showing phosphorylated PLCγ2 in cells treated with gef (1 μM) and R428 or Lapa for 24 hr. SE, short exposure; LE, long exposure.

  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2018 Dec 10;34(6):954-969.e4. [Abstract]

    Customer Validation
     Western blot showing PKCδ expression in nuclear extracts of GR4 and GR10 cells treated with 1 μM gef in combination with 2.5 μM R428 and 5 μM GW572016 (Lapa) for 24 hr.

  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]

    Customer Validation
     BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of TAM receptor (LDC1267 at 1 µM, UNC2250 at 5 µM, R428 at 5 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Dec 19;7(1):17770. [Abstract]

    Customer Validation
     Western blot analysis of pAXL level in H1299 cells treated with the indicated concentration of R428 for 1 h. Results are confirmed in three independent experiments.

  • 1/16

    Bemcentinib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jun 20;8(25):41064-41077. [Abstract]

    Customer Validation
     The expression of AXL in the PC3-DR and DU145-DR cells treated with R428 (1 μM) is analyzed by western blotting.

  • Bemcentinib