ACC2-IN-1
ACC2-IN-1 is an orally active, selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 of 1.9 nM against human targets. ACC2-IN-1 acts as a reducing agent to decrease malonyl-CoA levels in skeletal muscle and exhibits a favorable CYP450 inhibition profile. ACC2-IN-1 can be used in the research of type 2 diabetes.
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- CAS 番号: 2237229-78-4
- 分子式: C20H20ClN3O3S
- 分子量:417.91
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CYP2C19 18 μM (IC50) |
CYP2C9 13 μM (IC50) |
ACC2-IN-1 (compound 2e) potently inhibits human ACC2 with an IC50 of 1.9 nM and is 1026-fold selective over human ACC1[1].
ACC2-IN-1 (30 min) exhibits high metabolic stability, with 91% and 100% remaining after incubation in human and rat liver microsomes, respectively[1].
ACC2-IN-1 has an acceptable CYP450 inhibition profile, with no inhibition of CYP1A2, CYP2D6, or CYP3A4 at concentrations up to 20 μM, and IC50 values of 18 μM for CYP2C19 and 13 μM for CYP2C9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6[1]
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Dosage:1.0 mg/kg; 2.5 mg/kg
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Administration:p.o.; single dose
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Result:Reduced skeletal muscle malonyl-CoA levels by 20%.
Reduced skeletal muscle malonyl-CoA levels by 41%.
Achieved corresponding plasma drug levels of 1130 ng/mL and 2621 ng/mL for the 1.0 mg/kg and 2.5 mg/kg doses, respectively.
化学情報
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CAS 番号 2237229-78-4
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分子量 417.91
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分子式 C20H20ClN3O3S
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SMILES
ClC1=C2C(N=C(S2)OCC)=CC=C1OC3=CC=C(C=N3)/C=C/[C@H](C)NC(C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ACC2-IN-1 関連分類
HY-183919 関連分類
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