Celastramycin A (isomer)
Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 491600-94-3
- 分子式: C17H18Cl3NO3
- 分子量:390.69
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
化学情報
-
CAS 番号 491600-94-3
-
分子量 390.69
-
分子式 C17H18Cl3NO3
-
SMILES
O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CNC(Cl)=C2Cl
-
Structure Classification
-
Initial Source
Streptomyces strains
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Pullen C, et al., New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta. 2002 Nov;216(1):162-7. [Content Brief] [Content Brief]
[2]. Kikuchi H, et al., Revised structure and synthesis of celastramycin a, a potent innate immune suppressor. Org Lett. 2009 Apr 16;11(8):1693-5. [Content Brief] [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Celastramycin A (isomer) 関連分類
HY-N12905 関連分類
Powered by Bioz