SERPINI2 - serpin family I member 2 Gene

Also Known as MEPI; PI14; PANCPIN; TSA2004

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5276

About SERPINI2

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,441,933-167,476,963 (from NCBI)

This gene has 8 transcripts (splice variants), 104 orthologues and 36 paralogues. Restricted expression toward pancreas (RPKM 124.3).

Summary

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

SERPINI2 Products (3)

mRNA Protein Name
NM_001012303.3 NP_001012303.2 serpin I2 precursor
NM_001394327.1 NP_001381256.1 serpin I2 precursor
NM_006217.6 NP_006208.1 serpin I2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINI2 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (25 - 392)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
Protein Preferred Names Protein Names

serpin I2

  • myoepithelium-derived serine protease inhibitor

SERPINI2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
SERPINI2 O75830 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
SERPINI2 O75830 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
16713569
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H
21516116
Intra
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Intra
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Validated Y2H
32296183
Intra
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Intra
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINI2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71039 Serpin I2 Protein, Human (HEK293, His) O75830 (S19-L405 ) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Retinitis Pigmentosa 61

  • RP61

  • Retinitis Pigmentosa, Type 61
Cardiomyopathy, Dilated, 1o

  • Dilated Cardiomyopathy 1o

  • CMD1O

  • Dilated Cardiomyopathy With Ventricular Tachycardia

  • Cardiomyopathy, Dilated, With Ventricular Tachycardia

  • Cardiomyopathy, Dilated 1o

  • Cardiomyopathy, Dilated, Type 1o
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Neuroserpin Inclusion Bodies

  • FENIB

  • Encephalopathy, Familial, With Collins Bodies

  • Familial Dementia With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Collins Bodies
Corneal Dystrophy, Meesmann, 1

  • Meesmann Corneal Dystrophy

  • Mecd

  • Corneal Dystrophy, Meesmann Epithelial

  • Juvenile Hereditary Epithelial Dystrophy

  • Corneal Dystrophy, Juvenile Epithelial Of Meesmann

  • MECD1

  • Meesmann Corneal Dystrophy 1

  • Meesmann Corneal Epithelial Dystrophy

  • Meesmann Epithelial Corneal Dystrophy

  • Corneal Dystrophy, Juvenile Epithelial, Of Meesmann

  • Stocker-Holt Dystrophy

  • Meesman Dystrophy

  • Meesman'S Corneal Dystrophy

  • Juvenile Hereditary Epithelial Dystrophy Of Meesmann

  • Corneal Dystrophy, Meesmann 1

  • Juvenile Epithelial Corneal Dystrophy Of Meesmann

  • Mcd

  • Dystrophy, Corneal, Meesmann
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12730 SERPINI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20671 Serpini2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27182 Serpini2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SERPINI2 MGD MGI:1915181
Macaca mulatta SERPINI2 VGNC VGNC:77367
Canis familiaris SERPINI2 VGNC VGNC:46043
Felis catus SERPINI2 VGNC VGNC:68835
Bos taurus SERPINI2 VGNC VGNC:34482
Rattus norvegicus SERPINI2 RGD RGD:619897
Others SERPINI2 NCBI