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製品番号: HY-147840

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HDAC-IN-41

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC₅₀ values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity.

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CAS 番号: 2490309-83-4
分子式: C₂₀H₂₂N₄O₆S
分子量:446.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HDAC-IN-41 構造式

CAS 番号: 2490309-83-4

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

HDAC1

0.62 μM (IC₅₀)

HDAC3

0.62 μM (IC₅₀)

HDAC2

1.46 μM (IC₅₀)

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.98 μM Compound: 65	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
HCT-116	IC₅₀	0.77 μM Compound: 65	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
HEL	IC₅₀	0.41 μM Compound: 65	Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
HeLa	IC₅₀	1.5 μM Compound: 65	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
Jurkat	IC₅₀	0.77 μM Compound: 65	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
MOLT-4	IC₅₀	0.54 μM Compound: 65	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]
PC-3	IC₅₀	2.5 μM Compound: 65	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37487305]

体外実験

HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC₅₀ values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2490309-83-4
分子量 446.48
分子式 C₂₀H₂₂N₄O₆S
SMILES

O=S(C1=[N+]([O-])ON=C1OCCCCCC(NC2=C(N)C=CC=C2)=O)(C3=CC=CC=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ding Q, et al. Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity. Bioorg Chem. 2020 Nov;104:104235. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

HDAC-IN-41

1 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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HDAC-IN-41

MedChemExpress（MCE）の使用を引用している文献 HDAC-IN-41

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HDAC-IN-41 関連分類

HY-147840 関連分類