製品番号: HY-Y0399

L-ノルバリン

(別名: L-Norvaline; Norvaline)

カスタマーレビュー

Based on 1 Customer Validation

L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.0%
CAS 番号: 6600-40-4
分子式: C₅H₁₁NO₂
分子量:117.15

保管条件:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

L-Norvaline 構造式

CAS 番号: 6600-40-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TNF Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

L-Norvaline (250 mg/L, in drinking water for 2.5 months) reduces the amyloid-β deposition in the mouse hippocampus, reduces TNF-α expression, promotes the expression of PSD-95 protein, and ameliorates cognitive ability in 3 Tg-AD mouse models^[1].
L-Norvaline (20 mg/kg, every 3 days for 8 weeks, ip) exhibits antioxidant and anti-hyperglycemic effects in rats HFD and STZ (HY-13753) induced hyperglycemia models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

3 Tg-AD mouse models^[1]
Dosage:

250 mg/L
Administration:

drinking water for 2.5 months
Result:

Increased freezing time in the fear conditioning test.

Animal Model:

HFD and STZ (HY-13753) induced hyperglycemia rat models^[2]
Dosage:

20 mg/kg
Administration:

every 3 days for 8 weeks, ip
Result:

Decreased the level of blood glucose, lipids and malondialdehyde (MDA).

化学情報

CAS 番号 6600-40-4
性状 Solid
分子量 117.15
分子式 C₅H₁₁NO₂
Color White to off-white
SMILES

N[C@@H](CCC)C(O)=O
別名

L-Norvaline; Norvaline
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

溶剤 & 溶解度

体外:

H₂O : 50 mg/mL (426.80 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.5361 mL

42.6803 mL

85.3606 mL

5 mM

1.7072 mL

8.5361 mL

17.0721 mL

10 mM

0.8536 mL

4.2680 mL

8.5361 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (426.80 mM); Clear solution; Need ultrasonic

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Polis B, et al., L-Norvaline, a new therapeutic agent against Alzheimer's disease. Neural Regen Res. 2019 Sep;14(9):1562-1572. [Content Brief]

[2]. Javrushyan H, et al., Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Exp Mol Pathol. 2022 Jun;126:104763. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	8.5361 mL	42.6803 mL	85.3606 mL	213.4016 mL
	5 mM	1.7072 mL	8.5361 mL	17.0721 mL	42.6803 mL
	10 mM	0.8536 mL	4.2680 mL	8.5361 mL	21.3402 mL
	15 mM	0.5691 mL	2.8454 mL	5.6907 mL	14.2268 mL
	20 mM	0.4268 mL	2.1340 mL	4.2680 mL	10.6701 mL
	25 mM	0.3414 mL	1.7072 mL	3.4144 mL	8.5361 mL
	30 mM	0.2845 mL	1.4227 mL	2.8454 mL	7.1134 mL
	40 mM	0.2134 mL	1.0670 mL	2.1340 mL	5.3350 mL
	50 mM	0.1707 mL	0.8536 mL	1.7072 mL	4.2680 mL
	60 mM	0.1423 mL	0.7113 mL	1.4227 mL	3.5567 mL
	80 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6675 mL
	100 mM	0.0854 mL	0.4268 mL	0.8536 mL	2.1340 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-ノルバリン

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TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

L-Norvaline 関連分類

HY-Y0399 関連分類