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製品番号: HY-178966

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STING agonist-48

STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC₅₀ = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.

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CAS 番号: 3027712-31-5
分子式: C₂₃H₁₆F₄N₂O₃S
分子量:476.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

STING agonist-48 構造式

CAS 番号: 3027712-31-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

STING agonist-48 (Compound 7k) (6.25-50 μM, 24 h) induces a dose-dependent increase in luciferase activity in THF-ISRE IRF3 cells, demonstrating a strong STING activation effect, but it does not induce luciferase activity in THF-ISRE STING-/- cells, where activity was completely lost, and it maintains a dose-dependent increase in THF-ISRE TRIF/MAVS-/- cells^[1].
STING agonist-48 does not cause any change in the thermal stability of the STING cytoplasmic domain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

STING agonist-48 (Compound 7k) (20 μg, i.m., once on day 0 and day 14) as a vaccine adjuvant can significantly enhance Th1/Th2-mediated antigen-specific humoral and cellular immune responses in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male and female C57BL/6 humanized STING (huSTING; 6-12 weeks) mice were intramuscularly immunized and boosted (at a two-week interval) with 50 μL of either detergent-split A/Victoria/210/2009 (H3N2, A/Vic)^[1].
Dosage:

20 μg
Administration:

I.m., 0 day, 14 days
Result:

Serum IgG1, IgG2, and total IgG titers were significantly increased in mice.
Increased secretion of IFN-γ, IL-4, and IL-5 from spleen cells.

化学情報

CAS 番号 3027712-31-5
分子量 476.44
分子式 C₂₃H₁₆F₄N₂O₃S
SMILES

O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Junaid A, et al. In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain. Eur J Med Chem. 2026 Jan 5;301:118201. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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