STING-IN-18
STING-IN-18 is an orally active STING inhibitor. STING-IN-18 exhibits an IC50 of 86 nM against STING in murine RAW-LuciaTM ISG cells. STING-IN-18 inhibits STING activation and blocks downstream signaling pathways. STING-IN-18 suppresses kidney injury and inflammation. STING-IN-18 can be used for the research of autoimmune and inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C18H18FN5O
- 分子量:339.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
STING-IN-18 (Compound QQ21) (1-5 μM; 14 h) inhibits the downstream signaling pathway of STING in RAW264.7 and THP-1 cells, and reduces the levels of IFNβ, TNFα, IL6 and CXCL10[1].
STING-IN-18 (2.5-5 μM; 24 h) reduces Cisplatin (HY-17394)-induced ROS production in THP-1 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 and THP-1
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Concentration:1 and 5 μM
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Incubation Time:Pretreated for 2 h, and treated with MSA-2 (HY-136927) for 14 h.
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Result:Inhibited the mRNA levels of FNβ, TNFα, IL6, and CXCL10 in a dose-dependent manner.
STING-IN-18 (10 mg/kg; i.p.; 4 days) effectively alleviates Cisplatin (HY-17394)-induced acute kidney injury in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (male, 8 weeks old, acute kidney injury model induced by Cisplatin (HY-17394) )[1]
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Dosage:10 mg/kg
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Administration:i.p.; daily; 4 days
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Result:Alleviated kidney enlargement and ischemic symptoms. Reduced elevated blood urea nitrogen (BUN) and serum creatinine levels.
Inhibited cisplatin-induced upregulation of IFNβ and TNFα protein levels.
Mitigated renal injury observed via H&E staining.
化学情報
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分子量 339.37
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分子式 C18H18FN5O
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SMILES
FC1=CC=C2C(C(NC(C3=NC=C(NC4CCCC4)N=C3)=O)=CN2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STING-IN-18 関連分類
HY-181057 関連分類
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