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United States

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製品番号: HY-169432

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TET-13

TET-13 is a positive allosteric modulator of GABA_A receptor with an EC₅₀ of 5.65 μM, lower than that of Etomidate (EC₅₀: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₅H₁₆N₂O₃S
分子量:304.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

TET-13 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

TET-13 (1 mg/mL, 0-30 min) is rapidly metabolized in SD rat plasma with a half-life T_1/2 of 0.48 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

TET-13 (1.2 mg/kg for mice, 1.725 mg/kg for rats, i.v.) shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively), with a faster recovery than Etomidate^[1].
TET-13 (1.38 mg/kg, i.v.) shows little inhibition on cortisone of rat serum, indicating it has no effect on cortisol biosynthesis^[1].
TET 13 (22 mg/kg/h) continuous infusion induces shorter recovery times and walking times than Etomidate in rats at 0.5, 1 and 2 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice, rats^[1]
Dosage:

2.5 ×ED₅₀ (ED₅₀: 0.48 mg/kg (mice) and 0.69 mg/kg, (rats))
Administration:

Intravenous injection (i.v.)
Result:

Exhibited faster recovery compared to Etomidate (the times to walk: 27.88 s and 107.80 s, respectively) in mice.
Showed the incidence of myoclonus is 100% in mice.
Showed faster onset time (3.04 s) than etomidate in rats.
Showed the incidence of myoclonus was 0 % in rats.

化学情報

分子量 304.36
分子式 C₁₅H₁₆N₂O₃S
SMILES

COC(CSC(C1=CN=CN1[C@H](C)C2=CC=CC=C2)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhu, et al. Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression. Bioorganic chemistry. 2024, 154, 107997. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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