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Necitumumab

(Synonyms: 11F8; IMC-11F8; LY3012211)
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Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer.

For research use only. We do not sell to patients.

  • Purity: 99.90%
  • CAS No.: 906805-06-9
  • Molecular Weight:144.78 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Necitumumab
  • Experimental Validation Results for Necitumumab
  • Experimental Validation Results for Necitumumab
  • Necitumumab Chemical Structure
    Necitumumab Chemical Structure
CAS No.: 906805-06-9
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Necitumumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human ERBB1/EGFR/HER1, His Tag can bind Necitumumab. The EC50 for this effect is 11.47 ng/mL.

  • 1/16

    Flow Cytometry analysis of A431 cells labelling ERBB1/EGFR/HER1 (red) with Necitumumab (anti-ERBB1/EGFR/HER1) (HY-P9964). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • Necitumumab Chemical Structure
    1/16
  • Necitumumab
  • Immobilized Human ERBB1/EGFR/HER1, His Tag can bind Necitumumab. The EC50 for this effect is 11.47 ng/mL.
  • Flow Cytometry analysis of A431 cells labelling ERBB1/EGFR/HER1 (red) with Necitumumab (anti-ERBB1/EGFR/HER1) (HY-P9964). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.