CSNK1G1 - casein kinase 1 gamma 1 Gene

Also Known as CK1gamma1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53944

About CSNK1G1

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,165,525-64,356,173 (from NCBI)

This gene has 18 transcripts (splice variants), 302 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 6.6), thyroid (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a member of the Casein Kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]

CSNK1G1 Products (4)

mRNA Protein Name
NM_001329605.2 NP_001316534.1 casein kinase I isoform gamma-1 isoform 2
NM_001329606.2 NP_001316535.1 casein kinase I isoform gamma-1 isoform 1
NM_001329607.2 NP_001316536.1 casein kinase I isoform gamma-1 isoform 3
NM_022048.5 NP_071331.2 casein kinase I isoform gamma-1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
25500533 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1G1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (44 - 289)

CK1gamma_C

CK1gamma_C: Casein kinase 1 gamma C terminal (332 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

casein kinase I isoform gamma-1

CSNK1G1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSNK1G1 Q9HCP0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
CSNK1G1 Q9HCP0 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
CSNK1G1 Q9HCP0 CSNK1G3 Homo sapiens Q9Y6M4
Anti Tag CoIP
33961781
Intra
CSNK1G1 Q9HCP0 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra
CSNK1G1 Q9HCP0 CSNK1G2 Homo sapiens P78368
Pull Down
32707033
Intra
CSNK1G1 Q9HCP0 CSNK1G2 Homo sapiens P78368
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSNK1G1 Proteins

Cat. No. 상품명 Accession Purity
HY-P76850 CSNK1G1 Protein, Human (Active, sf9, His-GST) Q9HCP0-1 (M1-K422) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Aortic Valve Prolapse
Gm1-Gangliosidosis, Type I

  • Gm1 Gangliosidosis Type 1

  • Beta-Galactosidase-1 Deficiency

  • Infantile Gm1 Gangliosidosis

  • GM1G1

  • Gangliosidosis, Generalized Gm1, Type 1

  • Glb1 Deficiency

  • Gangliosidosis Generalized Gm1 Type 1

  • Gangliosidosis, Generalized Gm1, Type I

  • Gangliosidosis, Generalized Gm1, Infantile Form

  • Beta Galactosidase Deficiency Type 1

  • Glb Deficiency Type 1

  • Gangliosidosis Generalized Gm1 Infantile Form

  • Norman-Landing Disease

  • Gm1-Gangliosidosis 1

  • Gangliosidosis Generalized Gm1 Infantile Type

  • Gm1-Gangliosidosis Infantile

  • Gangliosidosis Gm1 Infantile

  • Gangliosidosis, Gm1, Type I

  • Gangliosidosis Gm1

  • Beta-Galactosidase Deficiency
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS03248 CSNK1G1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21999 Csnk1g1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28516 Csnk1g1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CSNK1G1 RGD RGD:621404
Felis catus CSNK1G1 VGNC VGNC:80998
Bos taurus CSNK1G1 VGNC VGNC:50095
Macaca mulatta CSNK1G1 VGNC VGNC:81383
Mus musculus CSNK1G1 MGD MGI:2660884
Canis familiaris CSNK1G1 VGNC VGNC:54937
Others CSNK1G1 NCBI