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United States

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Cat. No.: HY-182317

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(+)-Mosnodenvir

(+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC₅₀ values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2043343-94-6
화학식: C₂₆H₂₂ClF₃N₂O₆S
분자량:582.98

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

(+)-Mosnodenvir Chemical Structure

CAS No.: 2043343-94-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	2.9 μM Compound: 9A, enantiomer 1	Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay	[PMID: 28105266]

Chemical Information

CAS No. 2043343-94-6
분자량 582.98
화학식 C₂₆H₂₂ClF₃N₂O₆S
SMILES

CS(C1=CC(OC)=CC(NC(C2=C(C=C(C=C2)Cl)OC)C(C(C3=C4)=CNC3=CC=C4OC(F)(F)F)=O)=C1)(=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Bouzidi HS, et al. Genomic surveillance reveals a dengue 2 virus epidemic lineage with a marked decrease in sensitivity to Mosnodenvir. Nat Commun. 2024;15(1):8667. Published 2024 Oct 9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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