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Cat. No.: HY-161381

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PDE4-IN-15

PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC₅₀ = 0.17 μM) and has anti-TNF-α activity (EC₅₀ = 0.19 μM). PDE4-IN-15 has a good skin permeability.

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CAS No.: 3034837-89-0
화학식: C₂₃H₃₀O₆
분자량:402.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PDE4-IN-15 Chemical Structure

CAS No.: 3034837-89-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC₅₀ = 0.17 μM) and has anti-TNF-α activity (EC₅₀ = 0.19 μM). PDE4-IN-15 has a good skin permeability^[1].

IC₅₀ & Target

PDE4

All Phosphodiesterase (PDE) Isoforms :

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	CC₅₀	>180 μM Compound: 7b-1	Cytotoxicity against human PBMC cells by MTT assay Cytotoxicity against human PBMC cells by MTT assay	[PMID: 38489246]
PBMC	EC₅₀	0.19 μM Compound: 7b-1	Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 38489246]

Chemical Information

CAS No. 3034837-89-0
분자량 402.48
화학식 C₂₃H₃₀O₆
SMILES

OC[C@H]1C2=C(O[C@@H]1C3=CC(OCC)=C(C=C3)OC)C(OCC)=CC(CCCO)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chenming Gu, et al. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. J Med Chem. 2024, 67, 6. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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CAS No.:
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Purity:
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PDE4-IN-15

All Phosphodiesterase (PDE) Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PDE4-IN-15 Related Classifications

HY-161381 Related Classifications