Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi
- J Gen Appl Microbiol. 2021 Jul 31;67(3):114-117. doi: 10.2323/jgam.2020.08.004.
- 1. Graduate School of Infection Control Sciences, Kitasato University.
- 2. Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
- 3. Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
- 4. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
- 5. Research Center for Biology, Indonesia Institute of Sciences (LIPI).
- 6. School of Tropical Medicine and Global Health, Nagasaki University.
- 7. Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
- 8. Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) with an IC50 value of 3.4 μM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC50 value of 47.6 μM.
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