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Cat. No.: HY-155825

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LPE-1

LPE-1 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 0.65 μM. LPE-1 inhibits the proliferation of gastric cancer, liver cancer and prostate cancer cells, and shows no activity against a subset of gastric cancer cells. LPE-1 is applicable for the research of gastric cancer, liver cancer and prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1637373-70-6
Formula: C₁₃H₁₀N₆S₃
Molecular Weight:346.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LPE-1 Chemical Structure

CAS No.: 1637373-70-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

LPE-1 (Compound Ⅰ-12) (72 h) inhibits the proliferation of MGC-803 (IC₅₀ = 7.85 μM), HGC-27 (IC₅₀ = 5.16 μM), HepG2 (IC₅₀ = 5.71 μM) and PC-3 (IC₅₀ = 7.21 μM) cells, but shows no detectable activity against SGC-7901 cells (IC₅₀ >128 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1637373-70-6
Molecular Weight 346.45
Formula C₁₃H₁₀N₆S₃
SMILES

N#CC=1C(=NC(=NC1C=2SC=CC2)SCC#C)NNC(=S)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu, et al. Pyrimidine derivatives containing semicarbazide and terminal alkyne structural units, and preparation methods and applications of pyrimidine derivatives. CN104119280 A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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