Cat. No.: HY-N1854

Pinobanksin 3-acetate

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Pinobanksin 3-acetate is a flavanone and flavonoid ester with antioxidant activity. Pinobanksin 3-acetate is naturally present in Sonoran propolis, honey, medicinal plants, and forestry coproducts of Pinus caribaea. Pinobanksin 3-acetate exerts anti-colorectal cancer activity by modulating proliferation, apoptosis, cell cycle, and Wnt signaling pathways. Pinobanksin 3-acetate can be used for the research of colon cancer.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 52117-69-8
Formula: C₁₇H₁₄O₆
Molecular Weight:314.29

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pinobanksin 3-acetate Chemical Structure

CAS No.: 52117-69-8

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Wnt Isoforms :

In Vitro

Pinobanksin 3-acetate does not inhibit proliferation of murine B-cell lymphoma M12.C3.F6 cells in an MTT assay and does not induce apoptosis in these cells^[1].
Pinobanksin 3-acetate does not inhibit the growth of Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, or Candida albicans^[2].
Pinobanksin 3-acetate (5-150 μg/mL; 24-72 h) potently inhibits proliferation of human colon cancer SW480 cells in a time- and dose-dependent manner, with IC₅₀ values of 163.61 μg/mL at 24 h, 40.72 μg/mL at 48 h, and 45.56 μg/mL at 72 h^[3].
Pinobanksin 3-acetate (50, 100 μg/mL; 24 h) dose-dependently increases the apoptotic rate of human colon cancer SW480 cells^[3].
Pinobanksin 3-acetate (100 μg/mL; 24 h) alters the expression of 4912 genes in human colon cancer SW480 cells, with differential expression enriched in pathways linked to cell proliferation, apoptosis, and colorectal carcinogenesis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

murine B-cell lymphoma M12.C3.F6 cells
Concentration:

50 μM
Incubation Time:

12 h
Result:

Did not exhibit a pro-apoptotic effect in M12.C3.F6 cells, with no statistical difference from the DMSO vehicle control.

Cell Proliferation Assay^[3]

Cell Line:

human colon cancer SW480 cells
Concentration:

5 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL, 150 μg/mL
Incubation Time:

24 h, 48 h, 72 h
Result:

Exerted a significant inhibitory effect on SW480 cell proliferation in a time- and dose-dependent manner.
Exhibited IC₅₀ values of 163.61 μg/mL at 24 h, 40.72 μg/mL at 48 h, and 45.56 μg/mL at 72 h.

Apoptosis Analysis^[3]

Cell Line:

human colon cancer SW480 cells
Concentration:

50 μg/mL, 100 μg/mL
Incubation Time:

24 h
Result:

Induced early apoptosis in 32.50% of SW480 cells and late apoptosis in 9.55% of cells at 50 μg/mL after 24 h treatment.
Induced early apoptosis in 49.60% of cells and late apoptosis in 24.10% of cells at 100 μg/mL after 24 h treatment.
Increased the apoptotic rate in a dose-dependent manner.

Chemical Information

CAS No. 52117-69-8
Appearance Solid
Molecular Weight 314.29
Formula C₁₇H₁₄O₆
Color White to off-white
SMILES

O=C1[C@H](OC(C)=O)[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavanonols
Initial Source
- Animals
Sonoran propolis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Food Biosci

2026 Apr 15;80:108917.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (318.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1818 mL

15.9089 mL

31.8177 mL

5 mM

0.6364 mL

3.1818 mL

6.3635 mL

10 mM

0.3182 mL

1.5909 mL

3.1818 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alday E, et al. Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chem Biol Interact. 2015;242:35-44. [Content Brief]

[2]. Sinyeue C, et al. Polyphenol Content, Antioxidant, and Antibiotic Activities of Pinus Caribaea Morelet Forestry Coproducts. Nat Prod Commun. 2023;18(11):1-10.

[3]. Amellip M. Anticancer activity of propolis flavonoid pinobanksin-3-acetate against human colon cancer in vitro. Int J Biosci. 2015;7(2):45-55.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1818 mL	15.9089 mL	31.8177 mL	79.5444 mL
	5 mM	0.6364 mL	3.1818 mL	6.3635 mL	15.9089 mL
	10 mM	0.3182 mL	1.5909 mL	3.1818 mL	7.9544 mL
	15 mM	0.2121 mL	1.0606 mL	2.1212 mL	5.3030 mL
	20 mM	0.1591 mL	0.7954 mL	1.5909 mL	3.9772 mL
	25 mM	0.1273 mL	0.6364 mL	1.2727 mL	3.1818 mL
	30 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6515 mL
	40 mM	0.0795 mL	0.3977 mL	0.7954 mL	1.9886 mL
	50 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5909 mL
	60 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	80 mM	0.0398 mL	0.1989 mL	0.3977 mL	0.9943 mL
	100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7954 mL

Keywords

Pinobanksin 3-acetate

1 Cited Publications

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Pinobanksin 3-acetate

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Publications Citing Use of MedChemExpress (MCE) Pinobanksin 3-acetate

All Wnt Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Pinobanksin 3-acetate Related Classifications

HY-N1854 Related Classifications