FGF-22

FGF-22 is a keratinocyte-preferred ligand of the FGF-7 subfamily that signals through FGFR1c and FGFR2c. It is expressed in skin, hair follicles, cerebellar granule cells and pancreas; in the brain it has been implicated in excitatory synapse organization and protection against oxidative stress, and in skin it influences hair-cycle progression and keratinocyte biology. The FGF22 locus has shown genetic association with Parkinson's disease, and altered expression has been reported in tumors and dermatological disorders. Recombinant FGF-22 supports hair-follicle research, FGFR2c binding studies, neuronal culture models and investigations of its proposed synaptogenic activity.