PU-20F

Cat. No.: HY-121706: Data Sheet Handling Instructions
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PU-20F is a Hsp90 inhibitor with an EC₅₀ of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research.

For research use only. We do not sell to patients.

PU-20F Chemical Structure

CAS No. : 422508-29-0

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Purity & Documentation
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Description

IC₅₀ & Target^[1]

HSP90

6.8 μM (EC₅₀)

In Vitro

PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC₅₀ of 6.8 μM^[1].
PU-20F (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC₅₀ of 23 μM^[1].
PU-20F induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC₅₀ of 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

417.44

Formula

C₂₀H₂₄FN₅O₄

CAS No.

422508-29-0

SMILES

FC=1N=C(N)C=2N=C(N(C2N1)CC3OCCC3)CC4=CC(OC)=C(OC)C(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chiosis G, et al. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem. 2002;10(11):3555-3564. [Content Brief]

PU-20F Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU-20F422508-29-0HSPHeat shock proteinsHsp90breast cancer cellsMCF-7 human breast cancer cellsgeldanamycinHer2 tyrosine kinasebreast cancerInhibitorinhibitorinhibit

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