The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro

  • Br J Pharmacol. 1992 Jan;105(1):3-5. doi: 10.1111/j.1476-5381.1992.tb14199.x.
K D Keegan  1 ,  G N Woodruff ,  R D Pinnock
Affiliations
  • 1. Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge.
PMID: 1375857 DOI: 10.1111/j.1476-5381.1992.tb14199.x
Abstract

Intra- and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine-sensitive neurones were encountered which were potently excited by bath application of the NK3 receptor agonist, senktide. On these senktide-sensitive neurones, NK1 and NK2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.

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