Benzylamides from Salvadora persica

  • Arch Pharm Res. 2006 Nov;29(11):952-6. doi: 10.1007/BF02969277.
Ashraf Taha Khalil  1
Affiliations
  • 1. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. [email protected]
PMID: 17146962 DOI: 10.1007/BF02969277
Abstract

A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, N1,N4-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate Antibacterial activity against Escherichia coli.

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