Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis

  • J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6. doi: 10.1080/10286020801966591.
Zheng-Fu Zhang  1 ,  Zong-Gen Peng ,  Lei Gao ,  Biao Dong ,  Jian-Rui Li ,  Zhuo-Yong Li ,  Hong-Shan Chen
Affiliations
  • 1. Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Beijing, China.
PMID: 18464075 DOI: 10.1080/10286020801966591
Abstract

During the study of anti-HIV-1 active components of the aqueous extracts of the roots of Salvia yunnanensis, three new derivatives of Polyphenols, namely: methyl salvianolate A (2), ethyl salvianolate A (3) and cis-lithospermic acid (5) were isolated along with two known Polyphenols, salvianolic acid A (1) and lithospermic acid (4) their structures were elucidated on the basis of NMR and MS spectral analyses. The anti-HIV-1 activities of the 5 Polyphenols were tested for the inhibition of P24 antigen in HIV-1 infected MT-4 cell cultures and HIV-1 replicative Enzymes in vitro.

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