Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

  • Fitoterapia. 2009 Jul;80(5):290-6. doi: 10.1016/j.fitote.2009.03.007.
M J Park  1 ,  K S Gwak ,  I Yang ,  K W Kim ,  E B Jeung ,  J W Chang ,  I G Choi
Affiliations
  • 1. Dept of Forest Sciences, Seoul National University, Gwanakgu, Seoul, Republic of Korea.
PMID: 19345255 DOI: 10.1016/j.fitote.2009.03.007
Abstract

The Antifungal effects of citral, eugenol, nerolidol and alpha-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the Antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess Antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.

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