Cat. No.: HY-N5142

α-Terpineol

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation.

For research use only. We do not sell to patients.

Purity: 99.74%
CAS No.: 98-55-5
Formula: C₁₀H₁₈O
Molecular Weight:154.25

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

α-Terpineol Chemical Structure

CAS No.: 98-55-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NF-κB Isoforms :

All Antibiotic Isoforms :

All AMPK Isoforms :

In Vitro

α-Terpineol (1-10 µM, 20 h) exerts anti-inflammatory effects in LPS-stimulated mouse peritoneal macrophages by inhibiting the NF-κB signaling pathway^[4].
α-Terpineol (0.06-0.125% v/v, 48 h) inhibits the growth of G. vaginalis (MIC = 0.06%) and C. albicans (MIC = 0.125%), showing antimicrobial activity comparable to Clotrimazole (HY-10882) ((v/v) represents volume/volume concentration, indicating the proportion of α-Terpineol in the culture medium)^[4].
α-Terpineol (1-100 μM, 24 h) inhibits AMPK phosphorylation, activates SREBP-1, and promotes lipid synthesis in HepG2 cells^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[7]

Cell Line:

HepG2 cells (hepatocellular carcinoma)
Concentration:

1, 10, 100 μM
Incubation Time:

24 h
Result:

Inhibited AMPK phosphorylation, promoted p70S6K phosphorylation, and increased SREBP-1 maturation.

Real Time qPCR^[7]

Cell Line:

HepG2 cells (hepatocellular carcinoma)
Concentration:

1, 10, 100 μM
Incubation Time:

24 h
Result:

Upregulated lipid synthesis-related genes Srebf-1c, Acc, Fasn, Scd-1.

In Vivo

α-Terpineol (6.25-50 mg/kg, p.o., single administration) exhibits antidiarrheal activity by exerting anticholinergic effects, blocking PGE2 and GM1 receptors, and interacting with cholera toxin, thereby reducing castor oil-induced diarrhea in a mouse model of acute diarrhea^[5].
\ α-Terpineol (56 mg/kg, i.p., single administration) provides short-term relief of mechanical pain in a mouse model of neuropathic pain induced by chronic constriction injury^[6].
α-Terpineol (100 mg/kg and 500 mg/kg, p.o., once daily for 2 weeks) induces fatty liver and promoted hepatic lipid accumulation in C57BL/6 mice^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Castor oil-induced acute diarrhea Swiss mouse model^[5]
Dosage:

6.25, 12.5, 25, 50 mg/kg
Administration:

Oral gavage (p.o.), single dose
Result:

Significantly reduced total stool amount (55%, 48%, 44%, 24%) and diarrhea rate (47%, 66%; 56%, 10%). All doses significantly decreased castor oil-induced enteropooling (46%, 78%, 66%, 41%)

Animal Model:

Neuropathic pain C57BL/6 mouse model induced by Chronic Constriction Injury^[6]
Dosage:

56 mg/kg
Administration:

ntraperitoneal injection (i.p.), single dose
Result:

Complete reversal of mechanical allodynia at 30 min, returning to baseline at 2 h, partial reversal at 3 h, no significant effect at 6 h.

Animal Model:

C57BL/6 mice^[7]
Dosage:

100 mg/kg and 500 mg/kg
Administration:

Oral gavage (p.o.), once daily, for 2 weeks
Result:

Increased hepatic triglyceride (TG) levels by 2-fold and serum TG levels by 25% (500 mg/kg);
Induced microvesicular steatosis in the liver, and enhanced neutral lipid accumulation as revealed by Oil Red O staining.

Chemical Information

CAS No. 98-55-5
Appearance <31°C Solid,>35°C Liquid
Molecular Weight 154.25
Formula C₁₀H₁₈O
Color Colorless to off-white
SMILES

OC(C)(C)C1CC=C(C)CC1
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
- Plants
- Saururaceae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Sci Rep

α-terpineol induces apoptosis in melanoma cells and its underlying mechanism. [Abstract]

2026 Jan 3;16(1):4278. PMID: 41484167
Microbiol Spectr

Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin. [Abstract]

2025 Sep 30:e0082525. PMID: 41025831

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1296.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.4830 mL

32.4149 mL

64.8298 mL

5 mM

1.2966 mL

6.4830 mL

12.9660 mL

10 mM

0.6483 mL

3.2415 mL

6.4830 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park SN, et al. Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria. Anaerobe. 2012 Jun;18(3):369-72. [Content Brief]

[2]. Park MJ, et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. Fitoterapia. 2009 Jul;80(5):290-6. [Content Brief]

[3]. Held S, et al. Characterization of alpha-terpineol as an anti-inflammatory component of orange juice by in vitro studies using oral buccal cells. J Agric Food Chem. 2007 Oct 3;55(20):8040-6. [Content Brief]

[4]. Trinh HT, et al. Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation. Planta Med. 2011 Dec;77(18):1996-2002. [Content Brief]

[5]. Dos Santos Negreiros P, et al. Antidiarrheal activity of α-terpineol in mice. Biomed Pharmacother. 2019 Feb;110:631-640. [Content Brief]

[6]. Bilbrey JA, et al. Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: possible cannabinoid receptor involvement. Psychopharmacology (Berl). 2022 May;239(5):1475-1486. [Content Brief]

[7]. Choi YJ, et al. α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway. Food Chem Toxicol. 2013 May;55:129-36. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.4830 mL	32.4149 mL	64.8298 mL	162.0746 mL
	5 mM	1.2966 mL	6.4830 mL	12.9660 mL	32.4149 mL
	10 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	15 mM	0.4322 mL	2.1610 mL	4.3220 mL	10.8050 mL
	20 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	25 mM	0.2593 mL	1.2966 mL	2.5932 mL	6.4830 mL
	30 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	40 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	50 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	60 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	80 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	100 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL

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α-Terpineol

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Publications Citing Use of MedChemExpress (MCE) α-Terpineol

All NF-κB Isoforms

All Antibiotic Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility