Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

  • Bioorg Med Chem Lett. 2009 Jun 1;19(11):3067-71. doi: 10.1016/j.bmcl.2009.04.024.
Eric A Tanifum  1 ,  Alexander Y Kots ,  Byung-Kwon Choi ,  Ferid Murad ,  Scott R Gilbertson
Affiliations
  • 1. Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555-0650, USA.
PMID: 19409779 DOI: 10.1016/j.bmcl.2009.04.024
Abstract

A series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli. The structure activity relationships around the basic core structure were examined and examples with better activity and potentially better pharmacological properties are presented.