STING-ing the antiviral pathway

  • J Mol Cell Biol. 2010 Jun;2(3):110-2. doi: 10.1093/jmcb/mjp048.
Peyman Nakhaei  1 ,  John Hiscott ,  Rongtuan Lin
Affiliations
  • 1. Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada.
PMID: 20022884 DOI: 10.1093/jmcb/mjp048
Abstract

The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens.

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