Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells

  • Biosci Biotechnol Biochem. 2012;76(3):598-600. doi: 10.1271/bbb.110800.
Keizo Yuasa  1 ,  Kaori Tada ,  Genki Harita ,  Tomomi Fujimoto ,  Masao Tsukayama ,  Akihiko Tsuji
Affiliations
  • 1. Department of Biological Science and Technology, The University of Tokushima Graduate School, Tokushima, Japan. [email protected]
PMID: 22451408 DOI: 10.1271/bbb.110800
Abstract

Although some polymethoxyflavones possess several important biological properties, including neuroprotective, Anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.

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