Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis

  • Bioorg Med Chem Lett. 2013 Nov 15;23(22):6111-3. doi: 10.1016/j.bmcl.2013.09.013.
Arndt W Schmidt  1 ,  Taylor A Choi ,  Gabriele Theumer ,  Scott G Franzblau ,  Hans-Joachim Knölker
Affiliations
  • 1. Department of Chemistry, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany.
PMID: 24084159 DOI: 10.1016/j.bmcl.2013.09.013
Abstract

A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.

Keywords
Anti-TB activity; Cholestanols; Inhibition; Steroids; Tuberculosis.