Regional brain distribution of [18F]GBR 13119, a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice

  • Eur J Pharmacol. 1989 Jul 18;166(2):331-4. doi: 10.1016/0014-2999(89)90078-2.
M R Kilbourn  1 ,  M S Haka ,  G K Mulholland ,  P S Sherman ,  T Pisani
Affiliations
  • 1. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109.
PMID: 2529129 DOI: 10.1016/0014-2999(89)90078-2
Abstract

We have examined the regional brain distribution of [18F]GBR 13119 (18F: beta +, T1/2 = 110 min), a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice. High levels of binding are observed in the striatum of both species, with striatum/cerebellum ratios of 3-4 at 60 min after injection of the radiotracer. Striatum radioactivity and striatum/cerebellum ratios are more than 50% reduced in C57BL/6 mice treated chronically with the neurotoxin MPTP. We conclude mice are an appropriate model for the in vivo study of the dopamine uptake system, and that [18F]GBR 13119 may be a suitable in vivo marker for degeneration of striatal dopaminergic neurons.

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