ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines

  • Sci Rep. 2017 Jun 7;7(1):2929. doi: 10.1038/s41598-017-03231-9.
Guangxiao Lin  1  2 ,  Shenglong Zhu  1  2 ,  Yikuan Wu  1  2 ,  Ci Song  1  2 ,  Wanjing Wang  1  2 ,  Yuan Zhang  1  2 ,  Yue-Lei Chen  3 ,  Zhao He  4  5  6
Affiliations
  • 1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.
  • 2. Synergistic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China.
  • 3. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China. [email protected].
  • 4. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China. [email protected].
  • 5. Synergistic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China. [email protected].
  • 6. School of Medicine, Jiangnan University, Wuxi, 214122, China. [email protected].
PMID: 28592877 DOI: 10.1038/s41598-017-03231-9
Abstract

All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition of breast Cancer cell for ER-positive than ER-negative cells, while triple negative breast Cancer cell such as MDA-MB-231 cell is poorly responsive to ATRA treatment. In this study, we found that combination of ω-3 free fatty acids (ω-3 FFAs) and ATRA exhibited synergistic inhibition of cell growth in three subtypes (ER+ MCF7, HER2+ SK-BR-3, Triple negative HCC1806 and MDA-MB-231 cells) of human breast Cancer cell lines. The combined treatment of ω-3 FFAs and ATRA resulted in cell cycle arrest. ω-3 FFAs combined with ATRA synergistically provoked cell Apoptosis via the Caspase signals but not p53. These findings suggest that combined chemotherapy of ω-3 FFAs with ATRA is beneficial for improvement of ATRA sensitivity in breast Cancer cells.

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