Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila

  • J Nat Prod. 2018 May 25;81(5):1260-1265. doi: 10.1021/acs.jnatprod.8b00135.
Yongle Du  1 ,  Ana L Valenciano  2 ,  Michael Goetz  3 ,  Maria B Cassera  2 ,  David G I Kingston  1
Affiliations
  • 1. Department of Chemistry and the Virginia Tech Center for Drug Discovery, M/C 0212 , Virginia Tech , Blacksburg , Virginia 24061 , United States.
  • 2. Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , Athens , Georgia 30602 , United States.
  • 3. Natural Products Discovery Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
PMID: 29738243 DOI: 10.1021/acs.jnatprod.8b00135
Abstract

An extract of Petradoria pumila from the Natural Products Discovery Institute was found to have moderate antiplasmodial activity, with an IC50 value between 5 and 10 μg/mL. The four new Diterpenoids petradoriolides A-D (1-4), the new benzotropolone petradoriolone (5), and the two known Lignans 6 and 7 were isolated after bioassay-directed fractionation. The structures and stereochemistries of the new compounds were determined by interpretation of NMR spectroscopy, mass spectrometry, and ECD spectra. Among these compounds, petradoriolide C (3) displayed the most potent antiplasmodial activity, with an IC50 value of 7.3 μM.