EZH2 inhibition promotes methyl jasmonate-induced apoptosis of human colorectal cancer through the Wnt/β-catenin pathway

Methyl jasmonate potentially induces the differentiation of human myeloid leukemia cells and inhibits their proliferation; it may induce the differentiation and Apoptosis of human lymphocytic leukemia cells, but does not exert a damaging effect on normal lymphocytes. In the present study, the Anticancer effect of methyl jasmonate on human colorectal Cancer cells was investigated. Cell viability and Apoptosis was assessed using a Cell Counting kit-8 assay and flow cytometry, respectively. Methyl jasmonate suppressed cell viability and induced Apoptosis in human colorectal Cancer cells. Additionally, methyl jasmonate increased the activation of Caspase-3, inhibited the expression levels of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and the Wnt/β-catenin pathway in human colorectal Cancer. Downregulation of EZH2 expression enhanced the Anticancer effect of methyl jasmonate on human colorectal Cancer cells through suppression of the Wnt/β-catenin pathway. Thus, EZH2 downregulation promotes the Anticancer effect of methyl jasmonate by inducing Apoptosis in human colorectal Cancer cells through the Wnt/β-catenin pathway.