Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens

  • J Nat Prod. 2019 Apr 26;82(4):1019-1023. doi: 10.1021/acs.jnatprod.8b00956.
Luke P Robertson  1  2 ,  Leonardo Lucantoni  2 ,  Sandra Duffy  2 ,  Vicky M Avery  2 ,  Anthony R Carroll  1  2
Affiliations
  • 1. Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.
  • 2. Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.
PMID: 30865443 DOI: 10.1021/acs.jnatprod.8b00956
Abstract

A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3- c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC50 values ranging from 1.7 to 4.7 μM.