Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

  • J Nat Prod. 2020 Nov 25;83(11):3435-3444. doi: 10.1021/acs.jnatprod.0c00929.
Guy Kleks  1  2 ,  Darren C Holland  1  2 ,  Emily K Kennedy  2  3 ,  Vicky M Avery  2  3 ,  Anthony R Carroll  1  2
Affiliations
  • 1. Environmental Futures Research Institute, Griffith University, Gold Coast, QLD 4222, Australia.
  • 2. Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.
  • 3. Discovery Biology, Griffith University, Brisbane, QLD 4111, Australia.
PMID: 33105995 DOI: 10.1021/acs.jnatprod.0c00929
Abstract

An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated Alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6). Three of the compounds (2-4) displayed moderate to potent antiplasmodial activity against both the chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Parasite strains of Plasmodium falciparum with an IC50 range of 0.57-1.7 μM and a high selectivity index against a human cell line (HEK293).