Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum

  • Chem Biodivers. 2025 Jun 3:e01481. doi: 10.1002/cbdv.202501481.
Yang Yao  1  2 ,  Chong-Xian Li  1 ,  Ya-Nan Duan  2 ,  Bin Zhou  2 ,  Jing-Ya Li  2 ,  Yao-Yue Fan  2 ,  Jian-Min Yue  1  2
Affiliations
  • 1. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
  • 2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China.
PMID: 40460281 DOI: 10.1002/cbdv.202501481
Abstract

The first comprehensive phytochemical investigation of Glochidion philippicum roots resulted in the isolation and characterization of seven new ent-cleistanthane-type Diterpenoids, glochiphenols A-G (1-7), along with two known analogs (8 and 9). Compounds 1-6 all feature a rare alkynyl group, with 1-3 representing highly aromatized 20-nor-ent-cleistanthane Diterpenoids. Their structures were elucidated by comprehensive spectroscopic analysis, and absolute configurations were established via electronic circular dichroism (ECD) calculations. Notably, bioactivity assays revealed that compounds 1 and 7 display potent inhibitory effects against DGKζ with IC50 values of 1.19 and 1.28 µM, respectively.

Keywords
DGKζ inhibitory; Glochidion philippicum; ent‐cleistanthane‐type diterpenoids; structural elucidation.
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