Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes

  • Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. doi: 10.1016/0014-2999(93)90999-x.
J dos S Cruz  1 ,  H Matsuda
Affiliations
  • 1. Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
PMID: 8223897 DOI: 10.1016/0014-2999(93)90999-x
Abstract

The effects of arenobufagin, a bufadienolide isolated from toad venom, on the Na+/K+ pump were investigated by recording the whole-cell current of dissociated cardiac myocytes. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1. Arenobufagin is 3.5-fold more potent than ouabain.

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