The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594

  • J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. doi: 10.1016/s0928-4257(98)80014-4.
M W Decker  1 ,  P Curzon ,  M W Holladay ,  A L Nikkel ,  R S Bitner ,  A W Bannon ,  D L Donnelly-Roberts ,  P S Puttfarcken ,  T A Kuntzweiler ,  C A Briggs ,  M Williams ,  S P Arneric
Affiliations
  • 1. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
PMID: 9789812 DOI: 10.1016/s0928-4257(98)80014-4
Abstract

ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.

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