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BLOC1S2 Protein, Human

Cat. No.: HY-P76171
COA Handling Instructions

BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged. The total length of BLOC1S2 Protein, Human (GST) is 99 a.a., with molecular weight of ~11.35 KDa.

For research use only. We do not sell to patients.

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Description

BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged. The total length of BLOC1S2 Protein, Human (GST) is 99 a.a., with molecular weight of ~11.35 KDa.

Background

BLOC1S2 protein is a vital component of the BLOC-1 complex, crucial for the normal biogenesis of lysosome-related organelles (LRO), including platelet dense granules and melanosomes. Together with the AP-3 complex, the BLOC-1 complex is essential for directing membrane protein cargos into vesicles formed at cell bodies, facilitating their delivery into neurites and nerve terminals. The BLOC-1 complex, in conjunction with SNARE proteins, is also implicated in neurite extension. As a part of the BORC complex, BLOC1S2 may contribute to the movement and localization of lysosomes at the cell periphery, associating with the cytosolic face of lysosomes and potentially recruiting ARL8B to couple lysosomes to microtubule plus-end-directed kinesin motors. Additionally, BLOC1S2 may play a role in cell proliferation as part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) and the BLOC-one-related complex (BORC), interacting with various components within these complexes, including BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5, SNAPIN, and IFT57.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

Q6QNY1-2 (M1-R99)

Gene ID
Molecular Construction
N-term
BLOC1S2 (M1-R99)
Accession # Q6QNY1-2
C-term
Synonyms
Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; BLOS2; CEAP
Molecular Weight

Approximately 11.35 kDa.

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

BLOC1S2 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
BLOC1S2 Protein, Human
Cat. No.:
HY-P76171
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