FADD Protein, Human (His)
FADD Protein, Human (His) is the recombinant human-derived FADD, expressed by E. coli , with His labeled tag.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
FADD Protein, Human (His) is the recombinant human-derived FADD, expressed by E. coli , with His labeled tag.
FADD is an apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting complex, called the death-inducing signaling complex (DISC), performs proteolytic activation of CASP8. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Additionally, FADD is involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. by similar content includes: FADD's function in DISC and its role in the apoptotic cascade.
Technical Parameters
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Species Human
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Source E. coli
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Tag His
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Accession
Q13158 (M1-S208)
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Gene ID8772
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Protein Length
Full Length
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Synonyms
FADD; Mediator Of Receptor-Induced Toxicity; Fas Associated Via Death Domain; FAS-Associated Death Domain Protein; MORT1; FAS-Associating Death Domain-Containing Protein; Growth-Inhibiting Gene 3 Protein; Mediator Of Receptor Induced Toxicity; GIG3; Fas-A
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AA Sequence
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
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Molecular Weight
Approximately 27 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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