GFAP Protein, Mouse (His-SUMO)

The GFAP protein is a member of the class III intermediate filament family and serves as a cell-specific marker critical for distinguishing astrocytes from other glial cells in the developing central nervous system. Its role as a marker is critical in defining the identity of astrocytes, highlighting their unique characteristics in a complex cellular environment. GFAP Protein, Mouse (His-SUMO) is the recombinant mouse-derived GFAP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of GFAP Protein, Mouse (His-SUMO) is 430 a.a., with molecular weight of ~65.9 kDa.

Glial Fibrillary Acidic Protein (GFAP), classified as a class-III intermediate filament, functions as a cell-specific marker crucial for distinguishing astrocytes from other glial cells, particularly during the development of the central nervous system. GFAP plays a pivotal role in the formation and maintenance of the cytoskeleton in astrocytes, contributing to their structural support and stability. Its expression is highly specific to astrocytes, making it a valuable marker in identifying these glial cells in various physiological and pathological contexts. Furthermore, GFAP has been reported to interact with SYNM, suggesting potential functional associations with proteins involved in cytoskeletal dynamics or cellular signaling pathways within astrocytes. This interaction adds a layer of complexity to the understanding of GFAP's role in astrocyte biology. Ongoing research may reveal additional details about the molecular mechanisms and functional implications of GFAP in the central nervous system.

Mouse

E. coli

N-6*His;N-SUMO

P03995 (M1-M430)

14580  [NCBI]

MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQKLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKDSKQEHKDVVM

Approximately 65.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.