NrdD Protein, E.coli (His)

The NrdD protein plays a key role in cellular processes by catalyzing the conversion of ribonucleotides into deoxyribonucleotides, an essential component required for DNA synthesis and repair. Various studies have demonstrated that NrdD contributes to the maintenance and replication of genetic material by promoting the conversion of ribonucleotides into their deoxyribonucleotide counterparts through its enzymatic activity. NrdD Protein, E.coli (His) is the recombinant E. coli-derived NrdD protein, expressed by E. coli , with N-His labeled tag. The total length of NrdD Protein, E.coli (His) is 712 a.a., with molecular weight of ~84.0 kDa.

NrdD is an enzyme that plays a crucial role in nucleotide metabolism by catalyzing the conversion of ribonucleotides into deoxyribonucleotides. This enzymatic activity is essential for DNA synthesis and repair processes within the cell. NrdD contributes to the balance of deoxyribonucleotide pools necessary for the accurate and efficient replication of DNA. The enzyme is capable of reducing each of the four common ribonucleoside triphosphates, underscoring its versatility in modifying a range of nucleotide substrates. It has to highlight NrdD's central role in nucleotide biosynthesis, emphasizing its significance in providing the precursors required for the synthesis and maintenance of DNA, which is fundamental for various cellular processes.

E.coli

E. coli

N-His

P28903 (1M-712G)

948755  [NCBI]

MTPHVMKRDGCKVPFKSERIKEAILRAAKAAEVDDADYCATVAAVVSEQMQGRNQVDINEIQTAVENQLMSGPYKQLARAYIEYRHDRDIEREKRGRLNQEIRGLVEQTNASLLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVQAHERGDIHYHDLDYSPFFPMFNCMLIDLKGMLTQGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASYNKHRKTAEEWNIPDAEGYANSRTIKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQESILRNRIAGLGKNRKTAVFPKLVFAIRDGLNHKKGDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVWENENGEQIHDGRNNLGVISLNLPRIALEAKGDEATFWKLLDERLVLARKALMTRIARLEGVKARVAPILYMEGACGVRLNADDDVSEIFKNGRASISLGYIGIHETINALFGGEHVYDNEQLRAKGIAIVERLRQAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGVVPGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAPYPPLANGGFICYGEYPNIQHNLKALEDVWDYSYQHVPYYGTNTPIDECYECGFTGEFECTSKGFTCPKCGNHDASRVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHLGNGQIG

Approximately 84.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.